Assessment of the state of vegetation cover of recultivated dumps of uranium deposits in Northern Kazakhstan.

The purpose of this study was to assess the processes of plant community formation on recultivated dumps of spent uranium-containing industrial waste from uranium deposit mines, as well as to identify the degree of impact of agro-climatic factors, agrochemical indicators of soils of recultivated dumps, and the level of residual ionizing radiation on the productivity of the emerging vegetation cover. Studies of plant colonization of recultivated Grachevsky and Shantobinsky uranium mine dumps located in Northern Kazakhstan were carried out. The mining and technical stage of reclamation consisted of planning a dump with slopes of 15° and covering it with a 1 m layer of chestnut soil. In total, 30-35 plant species are present in the dumps, the projective coverage is approximately the same (56.6-70.0%), and the herbage density is 15-16.6 plants/100 m2. As a result of the measures taken to recultivate the dumps, the intensity of the background ionizing radiation at the Grachevsky mine dump was in the range of 25-35 µR/hr and at the Shantobinsky mine dump 10-25 µR/hr, which indicates compliance with safety standards. The plant species which can be used for artificial plant colonization of uranium-containing waste dumps, were identified.

A multicentric and nationwide predictive study role of T cell sub-population in the prevalence and prognosis of cryoglobulinemia among genotype 4 chronic hepatitis C patients.

The infection caused by the hepatitis C virus (HCV) is a significant global health concern. The prevailing genotype of HCV in Egypt is 4a, commonly referred to as GT-4a. A significant proportion exceeding 50% of patients infected with HCV experience extrahepatic manifestations (EHMs), encompassing a diverse range of clinical presentations. These manifestations, including essential mixed cryoglobulinemia (MC), can serve as initial and solitary indicators of the disease. The complete understanding of the pathogenesis of EHM remains unclear, with autoimmune phenomena being recognized as the primary causative factor. In this study, we examined the predictive significance of T-cell subpopulations in relation to the occurrence and prognosis of cryoglobulinemia in HCV patients. A total of 450 CHC genotype four treatment naïve patients were enrolled in this analytic cross-sectional study after thorough clinical, laboratory, and radiological examinations. All patients underwent laboratory investigations, including testing for cryoglobulin antibodies and measurements of CD4 and CD8 levels; two groups were described according to their test results: Group 1 consists of patients who have tested positive for cryoglobulin antibodies and Group 2 consists of patients who have tested negative for cryoglobulin antibodies. The exclusion criteria encompassed individuals with HIV infection or chronic HBV infection. Additionally, pelvi-abdominal ultrasonography was performed. Our study included 450 treatment naïve CHC patients (59% male, mean age 50.8 years). The patients were categorized according to their cryoglobulin antibodys test results into two groups: group A, CHC patients with cryoglobulin antibodies (Abs) negative (364 patients), and group B, CHC patients with cryoglobulin Ab positive (86 patients). Group B demonstrated a higher average age, elevated international normalized ratio, more prolonged duration of HCV infection, lower albumin, higher alanine aminotransferase, higher aspartate aminotransferase, higher bilirubin, lower CD8, lower CD4, and lower CD4:CD8 ratio. In contrast, 27 out of 86 (31.40%) patients in group B had symptoms; 85.8% had purpura and arthralgia, 74.3% had paresthesias, 86.7% had weakness, and 12.2% had non-Hodgkin's lymphoma. The levels of CD4 and CD8 were found to be decreased in chronic HCV patients with MC. T-cell subpopulation serves as a reliable indicator for assessing the prevalence and prognosis of MC in individuals with genotype 4 chronic hepatitis C. However, additional research is needed to further understand the development and spread of various emerging infectious diseases. Nevertheless, it is noteworthy that a critical threshold may exist beyond which EHM reaches a point of no return.

CAG repeat length in androgen receptor gene and male infertility in Egyptian patients.

The CAG repeat and its association with infertility has been debatable. Therefore, this study was planned to assess the distribution of CAG repeat expansion in Egyptian patients and to investigate its association with male infertility. Forty-five infertile men were eligible for the study in addition to 20 aged-matched fertile males as control. Semen analysis, scrotal sonography, assay of serum testosterone, follicle-stimulating hormone (FSH) and luteinising hormone (LH), and determination of the CAG repeat number within exon 1 of the androgen receptor (AR) gene were carried out. Statistically significant difference was found between infertile and control groups regarding sperm count, sperm motility, serum FSH level and CAG repeats (P < 0.05); statistically insignificant difference for the CAG repeats (P = 1.0) was found between oligozoospermic and asthenospermic groups; negative correlation was found between CAG repeat length and sperm count, and a positive correlation was found between CAG repeat length and serum FSH (P < 0.05). Our results validate the concept that long stretches of CAG repeat may be associated with lower AR function with derangement of sperm production, and this may contribute to male infertility in Egyptian men.

An integrated platform for bio-analysis and drug delivery.

The advances in the microelectronics fabrication allow the strong appearance of micro-electro-mechanical systems known as MEMS. MEMS enable the fabrication of smaller devices that are manufactured using standard micro-fabrication techniques similar to the ones that are used to create computer silicon chips. Several MEMS devices including micro-reservoirs, micro-pumps, cantilevers, rotors, channels, valves, sensors, and other structures have been designed, fabricated and tested from using materials that have been demonstrated to be biocompatible. This paper reviews the status of Micro-electronic and MEMS systems that can be used for adaptive drug administration. It presents different components and describes a possible implementation. Finally it presents a prototype that is termed ipill which stands intelligent pill.

Combined anterior interbody fusion and posterior pedicle screw fixation in patients with degenerative lumbar disc disease.

We reviewed 47 consecutive patients with degenerative lumbar disc disease. All patients were treated by anterior interbody fusion using an autogenous iliac bone graft in combination with posterior pedicle fixation but without a posterior fusion. There were 32 men and 15 women with a mean age of 44 (range 23-56) years. One third (n=15) of the patients had previous surgery. We saw complications in six patients including two with vascular injury. The mean follow-up was 2.2 years. Seventy-two per cent of the cases had a satisfactory clinical outcome, and the overall fusion rate was 97%.